NUCLEODUR phases

NUCLEODUR® high purity silica phases for HPLC

Features

	NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties: totally spherical particle shape outstanding surface microstructure high pressure stability low metal content NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
	NUCLEODUR® with 1.8 µm particle size for increased separation efficiency

Summary of available NUCLEODUR® phases
Phase	Modification	% C	pH range	Particle sizes [µm]	USP	Structure
C18 Gravity	octadecyl, high density coating, multi-endcapping	18	1–11	1.8 · 3 · 5	L1
C8 Gravity	octyl, high density coating, multi-endcapping	11	1–11	1.8 · 5	L7
C18 Isis	octadecyl, specially cross-linked modification, endcapped	20	1–10	1.8 · 3 · 5	L1
C18 Pyramid	octadecyl with polar endcapping	14	1–9	1.8 · 3 · 5	L1
PolarTec	octadecyl with embedded polar group	17	1–9	3 · 5	L1 L60
PFP	pentafluorophenyl-propyl with multi-endcapping	8	1–9	3 · 5	L43
Sphinx RP	bifunctional, balanced ratio of propylphenyl and octadecyl, endcapping	15	1–10	1.8 · 3 · 5	L1 L11
C18 HTec	octadecyl, high density coating, high capacity, multi-endcapping	18	1–11	1.8 · 3 · 5 7 · 10	L1
C18 ec	octadecyl, medium density, endcapping	17.5	1–9	3 · 5 and larger	L1
C8 ec	octyl, medium density, endcapping	10.5	1–9	3 · 5	L7
HILIC	ammonium – sulfonic acid	7	2–8.5	1.8 · 3 · 5
CN/CN-RP	cyano (nitrile) for NP and RP separations	7	1–8	3 · 5	L10
NH2/NH2-RP	aminopropyl for NP and RP separations	2.5	2–8	3 · 5	L8
SiOH	unmodified NUCLEODUR®	–		3 · 5 and larger	L3